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Methylation of p53 protein by KMT7/SET7 is the primary reported KMT-mediated methylation occasion on a non-histone protein 18 Since that discovery, several KMTs, as well as KDM1A, have been recognized as p53 regulators that methylate or demethylate p53 protein, making …
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In both proteins, the partitions of the lysine-binding channel are shaped by hydrophobic residues that have interaction in van der Waals interactions with the lysine facet chain (Determine 4b,c ). At the base of the channel is the methyltransfer pore, …
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